Cream Alternative to Botox

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MONDAY, June 20 (HealthDay News) — A more recently approved version of botulinum toxin type A beat the anti-wrinkle medication Botox in a trial that compared the respective powers of each in erasing those unwanted lines of aging around the eyes known as “crow’s feet.”

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“One month after treatment, on a two-to-one preference basis, patients picked Dysport over the Botox in terms of wrinkle improvement,” said study co-author Dr. Corey S. Maas, an associate clinical professor at the University of California, San Francisco, as well as a plastic surgeon with The Maas Clinic, based in San Francisco and Lake Tahoe.

“So, we can say that when it comes to addressing the smile lines around the eyes, the crow’s feet, at one month the Dysport is more effective than Botox,” Maas said. “And that’s a big deal, because Botox is such a recognized household name now. And it’s such a great drug. But when you have something that comes in that’s as good in some areas, let alone even better, it’s big news for all of us, both doctors and patients.”

Maas and his colleagues report the findings in the June 20 online edition of the Archives of Facial Plastic Surgery.

In 2002, the U.S. Food and Drug Administration first approved a particular form of botulinum toxin type A; this drug is popularly known as Botox and is manufactured by Allergan Inc.

An alternate version of the same botulinum toxin was approved in Europe in 2001 for general cosmetic applications. The drug, known as Dysport, is manufactured by Medicis Aesthetics; this version of botulinum was approved for use in the United States in 2009.

To compare the efficacy of both, the research team focused on 77 women and 13 men aged 18 and up between 2009 and 2010. None had previously undergone a facelift , brow lift or laser/chemical resurfacing. None had been exposed to botulinum in any form in the six months prior to the study launch, nor had any experienced adverse side effects as a result of previous exposure to botulinum.

Pre-procedure photographs were taken of all the patients, both while at rest and while contracting their foreheads and eyebrows. Wrinkling was subsequently graded on a five-point scale.

Next, the team the launched a so-called “split face” study, in which the right and left sides of each patient’s face were each exposed to one of the drugs. Calculating that the strength ratio of the two drugs is about three-to-one, the researchers injected 10 units of Botox into the crow’s feet region of one side of the face, compared with 30 units of Dysport on the other, according to the report.

One month following injection, the patients were asked to contract their muscles as hard as they could, while photographs were again taken.

The result: both the researchers and a majority of patients concurred that Dysport appeared to produce a better outcome. Specifically, two-thirds of the patients expressed a preference for Dysport, ranking Dysport nearly one point higher on the five-point wrinkling scale.

The authors noted, however, that when the patients relaxed their faces there was no appreciable difference between the Dysport and Botox sides.

“Now we want to be careful not to overplay this,” stressed Maas. “From our findings, it’s clear that there’s a better smoothing effect and clearing of lines around the eyes with Dysport. But does that also mean that Dysport is better at achieving the same thing around the mouth or forehead or neck? We really can’t make that conclusion.”

Maas added that, “the cost of the two amounts respectively are about the same. Maybe actually a little bit less for Dysport, but not substantially less.”

He also acknowledged that although the manufacturers of both drugs were approached to support the current investigation, only the maker of Dysport ultimately contributed funding to the effort.

“And what I would personally say about that,” noted Maas, “is that if you already own 90% of the market why would you fund a study where if you tied you lost? But I will add that Allergan didn’t like the dosing or the statistical analysis we used, despite the fact that I believe the body of scientific evidence supports the way we handled both.”

But Allergan issued a statement Monday that challenged the findings on several grounds, which included the small size of the study, the short length of the trial and, most importantly, the dosing ratio the researchers used when deciding how much of each product to use on the patients’ faces.

“It is important to understand that no two botulinum toxins are alike and each has a unique molecular structure, formulation, potency and safety profile,” the company said in its statement. “In fact, the U.S. FDA-required product labels for BOTOX Cosmetic and other botulinum toxins state that different botulinum toxin products are not interchangeable and no consistent dose ratio exists among botulinum toxin products.”

“The most significant flaws in this study’s design were the attempted dose conversion and injection pattern. In this study, patients were treated with 10 units of BOTOX Cosmetic and 30 units of Dysport. As stated above, BOTOX Cosmetic and Dysport are not interchangeable and there is no established dose conversion, meaning 10 units of BOTOX Cosmetic does not equal 30 units of Dysport. When patients are treated with BOTOX Cosmetic for its approved indication in the glabellar (vertical frown lines between the eyebrows), they typically receive 20 units, which is the FDA-approved dose. In addition to specific dosing regimens, BOTOX Cosmetic also has a unique injection pattern for proper administration, pending the treatment area and individual patient.”

Dr. Doris Day, a dermatologist with Lenox Hill Hospital in New York City, also cautioned that the attempt to analytically stack two “very similar” drugs against one another can pose difficulties.

Commenting on the study, she said, “The problem with any study trying to compare them is that there are variations in the reconstitution measures and final numbers of units used for each drug, and that can have a large impact on the final effect of the treatment. Because these are biologics, and because there are slight differences in the manufacturing process, there will be some differences in how the final product works.”

Day pointed out that both drugs are FDA-approved and have good safety track records to date.

Copyright 2011 HealthDay . All rights reserved.

SOURCES: Corey S. Maas, M.D., F.A.C.S., associate clinical professor, University of California, San Francisco, and plastic surgeon, The Maas Clinic, San Francisco and Lake Tahoe; Doris Day, M.D., dermatologist, Lenox Hill Hospital, and clinical assistant professor, dermatology, NYU Langone Medical Center, New York City; June 20, 2011, statement, Allergan Inc., Irvine, Calif.; June 20, 2011, Archives of Facial Plastic Surgery, online

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A Botox Jab may be a woman’s dream come true but you need to know about the negative side effects as well.

Botox (or Botulinum Toxin), as its name suggests, is a toxin produced by a bacteria called botulinum. It is inherently poisonous although in small quantities, the poison is actually quite safe.

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As Botox is a toxin (poison), it must be administered by a physician. Therefore it carries an exorbitant price – it can set you back $200-$300 per jab and that’s no small money by any standards.

Note that Botox jabs are only effective against wrinkles caused by facial actions. These include horizontal forehead creases, crow’s feet and vertical wrinkles of your upper lip. It is not effective against fine lines and other types of wrinkles.

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Bruising and swelling

Botox Can Cost Your Over Thousand Dollars

Botox injection usually starts at $500 for each treatment and require many treatments. Follow-up visits usually required due to the possible side-effects. The cost of a complete Botox can go up to several thousands dollar and not to mention the time visiting the doctor.

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Galvanic Treatment Can Be An Alternative

A less aggressive, but more safe anti-aging method is the galvanic treatment. By frequently using galvanic treatment, the skin can be firmed and more toned. This helps reduce wrinkles and sagging skin. Galvanic treatment works by using galvanic ions to bring nutrients deep into the skin

A small portable galvanic machine can give you a refreshing facial treatment within 20 minutes.

Galvanic Skin Technology Explained

Galvanic machine emits low electric currents, the anode (+) and the cathode (-). These positive and negative currents are able to bring nutritient deep into skin. The result of absorbing these skin nutrients is a more younger looking skin. No surgery and NO side-effects.

The galvanic technology used by the Galvanic machine has been scientifically recognized to improve the skin. The facial machine is effective for reducing fine lines and sagging skin. You may not see the positive effects from using the machine immediately, but after using it for several week you will see a better looking and natural skin.

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Cicatero said: 05-10-201210:26 PM

Originally Posted by basko

Interesting. I’ve had the exact opposite experience. My wife says my skin has never looked better. Are you using a quality aftershave balm? On the cheap Nivea is tough to beat. I also like Trumpers skin food and La Toja AS balm, but they’re not as inexpensive.

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I’m with basko, a three or four pass shave, a cold water rinse, a splash of witch hazel, some cheapo ASB and I’ve got a bright shining face for 12-14 hours. Maybe you should moisturize again later in the day.

… what a LOSER!

ryan2022 said: 05-11-201204:50 AM

Originally Posted by Cicatero

I’m with basko, a three or four pass shave, a cold water rinse, a splash of witch hazel, some cheapo ASB and I’ve got a bright shining face for 12-14 hours. Maybe you should moisturize again later in the day.

I think you guys might be right. I covered my face in moisturizer before bed, and my skin looks better. I usually use after shave balm as a moisturizer again later in the day, but I’m wondering if it isnt enough.

I’m thinking the DE shaving might not be beating me up, but it MIGHT be causing more dryness because it is a closer shave.

Maybe I need to up it a bit. I’m just NOT excited about going back to cartridge razors, although I had some good shaves with the atra/ trac II. theres just no heart.

ateace said: 05-11-201208:25 AM

I echo the suggestions for moisturizer. Nivea Sensitive balm works great, comes in a nice glass bottle and is dirt cheap.

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kbuzbee said: 05-11-201211:35 AM

Originally Posted by ryan2022

I think you guys might be right. I covered my face in moisturizer before bed, and my skin looks better. I usually use after shave balm as a moisturizer again later in the day, but I’m wondering if it isnt enough.

I think you’re on the right track. Given the exfoliation of DE shaving, I find my skin is smoother and softer than it ever was with a cart.

By the way, I use AOS balms and gels. They seem to work well for me.

Ken

Rooney 3/3 Finest, MdC, iKon OSS with Med Preps, AOS AS balm

Champion of Capua said: 05-11-201211:41 AM

Witch hazel, your face will love you for it

Chi Chi, get the yayo

HoosierTrooper said: 05-11-201212:09 PM

Hey, nothing wrong at all if the Trac II works for you. It’s all about finding what you get the best results with, nothing else. The Personna Bump Fighter handle is great, it’s heavier than the Gillette version and has a nice grippy handle.

Tom

Trying not to wear hearts on sleeves, but that’s the way it always seems to be

The salt and the steel of the breath of those not keeping still

Ruston said: 05-11-201212:50 PM

I also had some skin dryness and tightness until I switched to cold water rinse only. That seemed to do the trick.

Straight Rasier User said: 05-11-201201:20 PM

Interesting Post as my skin looks a lot better with either the Straight, DE or SE shaves.

However, the razor is not the reason.

I shower first and wash my face and make sure that the beard is wet.

I then finish my shower and get ready for the shave.

Sometimes, I was my face with a preshave soap after the lather is ready.

Then, I shave with a crappy CVS, Walgreen or Grocery Store Blade … in a Goodfella Razor (The Open Comb Razor I am currenty using).

Then, I rinse, lather, shave (WTG)

Then, I rinse, lather, shave (XTG)

Then, I rinse, lather, shave (Reverse-XTG)

Then, I rinse, lather, shave (ATG)

Then, I rinse, lather or use a non foaming gel and shave (buffing or J-Hooking)

Then, I rinse my face in Hot Water and clean my brush.

Then, I rinse my face in Cold Water and finish cleaning my brush.

Then, I put Witch Hazel on a pad and wipe my face, (Then, I am thinking about wiping my face with an Alum Block but I have not done that yet.).

Then, I put on Nivea, or Trumpers Skin Food or Corn Huskers.

Then, I put on some aftershave.

Then, I put on some cologne if I want.

Now I work in a office so I am not outside all of the time. But, sometimes I put some face lotion on my face later in the day.

But most of the time my face feels and looks soft and clean shaven.

BOTOC –

Straight Rasier User said: 05-11-201201:22 PM

Trac II or Mach 3 … if it works for you then Great.

Keep coming back for the other information you can you.

So what will you be thinking about selling?

EJ 89, some blades, … anything else? … Wait I am sorry but, my RAD kicked in.

BOTOC –

mhdena said: 05-11-201201:24 PM

Any non-alcohol balm should work, such as Nivea, Real Shaving Co., AOS.

I use all of these, and some Lubriderm lotion on top of that.

If your is not moisturized reapply.

Christoph said: 05-11-201201:31 PM

Everyone is different. And finding what works for you can take a long time. I am able to shave 6 or even 7 days a week and not have any problems. But in the past I have had times when shaving 7 days a week and perhaps not applying all that I know and shaving with proper care that I have felt a bit of hurt as a result.

DOn’t stop experimenting with things. One thing you could try is a few drops of Extra Virgin Olive Oil rubbed into the skin as a Pre-Shave Oil. While this is not necessarily a crucial thing for the average shaver, believe me it can’t hurt. And EVOO nourishes the skin. After shaving, there is no evidence whatsoever that you used it as a PSO. In fact it feels quite good. One thing I have found helpful is strictly following the method shaving cutting forms of Charles Roberts. Just google this and check it out, although you probably already have.

Good luck!

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Technical issue?

Microdermabrasion

Steve Fallek (Plastic Surgeon and Medical Director, Face Focus Medical Spa) gives expert video advice on: Why would I need microdermabrasion?; How long is a microdermabrasion treatment?; How do I prepare for microdermabrasion treatment? and more…

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What is “microdermabrasion”?

Microdermabrasion is a technique of removing the outer layer of skin usually the dead tissue or the exfoliated tissue from the outer layers of the face. It’s mostly done by acidticions and in a medispa it’s somewhere in the middle between the least invasive and most invasive procedures. Patients seem to like it as it improves the skin and gives a glowing complexion. It will not remove some of those darker areas of skin but generally gives a nice healthy glow to the skin.

Why would I need microdermabrasion?

Microdermabrasion works great for patients that have superficial wrinkles and some outer layers of skin that really need to be cleaned up. If you’re looking for a deep long-lasting treatment, microdermabrasion is not going to be the answer for you. If you’re looking for a healthy glow to your skin with very little down time, very little redness, then microdermabrasion’s probably a good treatment for you.

Does microdermabrasion hurt?

Microdermabrasion does not hurt at all. In fact, some patients like the way that microdermabrasion feels, and in fact no anesthetic is usually used. Patients are generally happy with the feel of microdermabrasion.

How long is a microdermabrasion treatment?

Usually with microdermabrasion it is a series of treatments, anywhere from four to five treatments really to see a nice great improvement in the skin. Microdermabrasion treatments should last about half an hour. For some patients it’ll be less, but depending on your esthetician and pre and post treatments, it can last up to about an hour.

How will my skin look and feel after a microdermabrasion treatment?

Microdermabrasion treatment will give you a healthy, glowing appearance for your skin and for your face. It will get rid of some of the dead cells on the outer layers of your face and of your skin. Again, it’s going to give you a nice healthy glow. Microdermabrasion is not going to give you a very long-term solution, such as a chemical peel or a laser, but if you’re looking for something simple, not too costly, and a nice quick improvement, then the treatment is a great alternative.

What are the risks associated with microdermabrasion?

If done properly by an accredited institution, there really are almost no side effects associated with microdermabrasion. The only complication is that certain patients are looking for a more significant result, and microdermabrasion doesn’t necessarily always give you a long-term lasting result.

What are the benefits of microdermabrasion?

The benefits of microdermabrasion are clean, healthy, glowing, radiant skin. In terms of long term effects, there are really no benefits. Microdermabrasion is considered strictly a cosmetic or beauty treatment. Therefore, if it makes you feel good, and makes you look good, then that’s about all the benefit to it.

Can I receive microdermabrasion after an IPL treatment?

Microderabrasion and IPL treatments are in some respects complimentary. You can certainly have both of them done, but essentially they work the same way. So I would usually stick with one of the treatments as opposed to combining both of the treatments. So I would stick with one session or one of microdermabrasions and then move to IPL or vice versa. I wouldn’t necessarily combine the two.

What post treatment should I do after receiving microdermabrasion?

There are a variety of substances that are available after microdermabrasion treatment, but the best thing to do is probably to use a hypoallergenic moisturizer and keep your skin clean. Save your money with regards to some of those post-microdermabrasion treatments. A good moisturizer will be your best post-care treatment.

How much will a microdermabrasion treatment cost?

Microderambrasion treatments usually cost anywhere from $200 to $500. Many medi-spas offer packages which can run up to $1,500. So check with your medi-spa. Again, most of them will run package treatments, at most, they will charge $200.

Thanks for watching Microdermabrasion For more how to videos, expert advice, instructional tips, tricks, guides and tutorials on this subject, visit the topic Skin Procedures .

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VIVITE Advanced Skin Care

Gentle and Effective Medical Grade Skin Care Solutions

VIVITE is the newest skin care introduction by Allergan Medical, a company with an extensive heritage in The Science of Rejuvenation. Allergan Medical are makers of physician-only skin care treatments: MD Forte, Prevage MD, anti-aging prescription Avage, as well as BOTOX Cosmetic . The VIVITE line extends the Allergan promise of scientifically formulated and clinically shown products that help promote beautiful, healthy skin.

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Exfoliates Hydrates Protects

Regular use of VIVITE with GLX Technology” helps exfoliate, hydrate, and protect your skin. VIVITE has been clinically shown to help stimulate the skin’s natural production of hyaluronic acid and collagen as well as help stimulate the production of epidermal growth factor, which are vital to healthy, new skin. The antioxidants help protect skin against destructive free radicals. The VIVITE System is recommended for all skin types and conditions.

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At Harvard Eye Associates, you will received the benefits of a free consultation with our Aesthetic RN, in a relaxed environment where your options will be thoroughly discussed and explained.

VIVITE Skin Care System

The VIVITE Skin Care System is an advanced skin care regimen based on exclusive GLX Technology, an ultra-charged formula matrix that helps infuse the skin with a glycolic compound and antioxidants to help optimize skin rejuvenation.

The VIVITE Skin Care System contains four products that exfoliate, hydrate, and protect. Exfoliation is important in removing non-productive cells from the skin’s outer layer to reveal healthy, new skin. Hydration is important in keeping skin smooth. Antioxidant protection is important in keeping skin from aging prematurely due to attack from free radicals present in environmental stressors.

VIVITE advanced skin care system is the only all natural product line with a facial cleanser, an anti-aging cream, and a wrinkle cream that use GLX Technology” to help maximize anti aging benefits

VIVITE Exfoliating Cleanser dissolves skin build-up with both chemical and mechanical exfoliation and contains exfoliating microbeads to more completely remove unproductive skin and allows new skin to flourish. VIVITE Exfoliating Facial Cleanser loosens the unproductive top layer of skin so you can scrub it away and reveal fresh, new skin. Contains 15% glycolic compound. To be used 2 to 3 times a week. On the days you are not using the VIVITE Exfoliating Facial Cleanser, you may want to cleanse with the VIVITE Daily Facial Cleanser which also contain 15% glycolic compound.

VIVITE Daily Antioxidant Facial Serum moisturizes and extends exfoliation to reduce the appearance of fine lines and wrinkles as well as provide antioxidant protection. VIVITE Daily Antioxidant Facial Serum is a regular application of glycolic compounds for hydration and renovation of the top skin layer. In addition, it provides antioxidant protection to fight premature aging. The VIVITE Daily Antioxidant Facial Serum contains 15% glycolic compound as well as green tea, pomegranate and licorice — all noted for their natural antioxidant properties — as well as chamomile and aloe to smooth and soften skin. To be used once daily, every morning. Perfect under makeup.

VIVITE Night Renewal Cream is an extra-rich formulation that promotes overnight maintenance and repair of skin tissues. It contains 20% glycolic compound as well as Vitamin C and Vitamine E. The VIVITE Night Renewal Cream also contains superoxide dismutase (SOD), an advanced antioxidant for effective topical protection against scavenging free radicals. To be used once daily, in the evening.

VIVITE Revitalizing Eye Cream is specially formulated to reduce the appearance of fine lines, wrinkles, and dark circles in the sensitive areas around the eye, as well as minimize the appearance of dark circles. It contains 10% glycolic compound in addition to caffeine to reduce puffiness and inflammation, peptides to tighten skin and interference pearls that reflect and diffuse light, improving the appearance of fine lines and wrinkles, as well as dark circles under the eyes. To be used twice daily, morning and evening.

VIVITE 70% Glycolic Chemical Facial Peel reduces the appearance of pores, lines and wrinkles. Its advanced formulation helps improve overall skin clarity and smoothness and helps reduce the appearance of fine lines and wrinkles. This time-released peel delivers high concentrations of glycolic acid and natural antioxidants without irritating side effects. Expect to see improvements in dry, tough texture, shallow or dull looking skin and fine lines. After this peel you may continue daily activities. Glycolic Acid is a naturally occurring alpha hydroxy acid that comes from sugar cane and has a pH level of 2.75. This 70% Glycolic Peel uses an exclusive GLX Technology that combines glycolic compound with natural antioxidants to form a formula matrix that deeply penetrates the skin to help promote production of hyaluronic acid, collagen, and epidermal growth factor, all of which are essential to the integrity and health of the skin. When glycolic is applied to the surface of the skin it dissolves properties of lipids that bind dead cells to the surface. Once these cells are released they shed off the surface revealing smooth healthy skin. The powerful antioxidants found in VIVITE 70% Glycolic Skin Peel help protect these new healthy skin cells.

VIVITE Vibrance Therapy is specially formulated with natural ingredients to help brighten and even skin tone while helping to reduce the appearance of fine lines and wrinkles in just 8 weeks.1 Restorative, antioxidant-rich cream works to help even out skin tone without hydroquinone. Contains 15% glycolic compound. To be used once or twice daily. For daytime use, apply on cleansed skin before VIVIT Daily Antioxidant Facial Serum. For evening use, apply before VIVIT Night Renewal Facial Cream.

VIVITE Vibrance Decollete Therapy is specially formulated to help improve the overall appearance of skin on the chest area in just 8 weeks, without hydroquinone.1 Protective antioxidants and revitalizing conditioners help improve the appearance of photodamaged skin on the chest area by reducing fine lines and wrinkles, dyschromia (discoloration), tactile roughness, and dryness and flaking.1 Contains 10% glycolic compound. To be used in the morning and evening, applied to cleansed chest area.

Our Promise

As always, Harvard Eye is first and foremost concerned about what is best for each individual patient. Call us today for your personalized consultation!

Harvard Eye Associates

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March 19, 2008 | Comment(s): 0

Recommended this article (6)

AGN

Allergan, Inc. ( AGN – Analyst Report ) is a global specialty pharmaceutical company that develops and commercializes innovative products for the eye care, neuro-modulator, skin care and other specialty markets. Allergan has been expanding into new therapeutic areas through acquisitions over the past few quarters. We believe these acquisitions will provide the company with the opportunity to drive growth in its existing business and to expand into new areas of business.

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The Inamed acquisition, in particular, should help strengthen Allergan’s position as a specialty pharmaceutical company. Allergan posted impressive results in 2007, and we are optimistic that strong trends in botox and the rest of the business will continue to keep Allergan delivering solid earnings growth over the next several years.

Allergan provided financial guidance for 2008. While the revenue guidance exceeded our expectations, the EPS guidance was in-line with our thinking. We expect 2008 to be a strong year for the company.

The stock currently trades at 21.6x our 2008 estimate of $2.58, a premium to its peers. We believe that the company deserves this premium given its strong top and bottom-line growth.

However, Allergan shares have been under pressure lately due to safety concerns surrounding the use of botox. Botox-related issues are likely to keep the shares in check in the near-term. We maintain a Hold rating on the stock with a price target of $60.

Arpita Dutt, CA, contributed to this report.

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Advanskin Multi Peptide Serum-Botox Alternative

Argireline has been clinically proven to reduce the appearance of fine lines and wrinkles by up to 27% and Matrixyl 3000 by up to 45% .

We are not aware of any other product on the market that combines these two active ingredients in such high concentrations.

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(15% Argireline and 6% Matrixyl 3000) Our Multi-Peptide Serum also includes Hyaluronic Acid for moisturizing benefits and Collagen production.

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Wage War on Free Radicals with Vitamin A & C

02-Apr-12 12:03

The human body is constantly under attack from free radicals. Free radicals are generated by normal cell metabolism and by exposure to environmental stress such as UV rays, smoke, and pollutants. Once formed, free radicals attack all structures (DNA, cell membranes, and proteins) within and on the surface of the b

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